Investigator, Lady Davis Institute
Assistant Professor, Department Human Genetics, Faculty of Medicine, McGill University
Through the computational analysis of genome-wide
data, Dr. Kleinman's lab tries to understand fundamental mechanisms
regulating gene expression, their interplay with genetic and epigenetic
factors, and how they cause disease. She is developing methods for the
analysis of large scale genomic and biological datasets, and apply them
to elucidate disease mechanisms.
lab's focus is on cancer and brain development, two areas where
deregulated gene expression plays a major role, and where unprecedented
amounts of data are being produced.
Major Research Activities
- Identification of cancer driver genes in molecularly stratified patient populations
- Elucidation of molecular signatures of therapeutic resistance in cancer
- Functional consequences of mutations in neurodevelopmental disease genes
L Binan et al. "Single-cell laser tag", Nature Communications, in press (2016).
CL Kleinman et al. “Fusion of TTYH1 with the C19MC microRNA cluster drives expression of a brain-specific DNMT3B in the embryonal brain tumour ETMR”, Nature Genetics 46:39-44 (2014).
CL Kleinman, J Majewski . Comment on "Widespread RNA and DNA Sequence Differences in the Human Transcriptome". Science 335:1302 (2012).