Major Research Activities
- Studying the control of endothelin-1 production by pulmonary microvascular endothelial cells in conditions simulating pulmonary hypertension.- Measuring pulmonary vascular surface area in pulmonary hypertension and studying the effects of exercise and medications.- Measuring novel mediators in pulmonary hypertension and studying factors that affect clinical outcomes.
Langleben D, Orfanos SE, Giovinazzo M, Hirsch A, Baron M, Senecal JL, Armaganidis A, Catravas JD. Pulmonary capillary endothelial dysfunction: Severity in pulmonary arterial hypertension related to connective tissue disease versus idiopathic pulmonary arterial hypertension. Arthr Rheumatism 2008;58:1156-1164.Star GP, Giovinazzo M, Langleben D. Bone morphogenic protein-9 stimulates endothelin-1 release from human pulmonary microvascular endothelial cells. A potential mechanism for elevated ET-1 levels in pulmonary arterial hypertension. Microvasc Res 2010;80:349-354.Fox BD, Shimony A, Langleben D. Meta-analysis of monotherapy vs. combination therapy for pulmonary arterial hypertension. Am J Cardiol 2011; in press.