Tel.: 514-340-8222 ext. 23438 (office)
ext. 23432 (Lab)
moulay.alaoui-jamali@mcgill.ca
Dr. Moulay Alaoui-Jamali
 
Senior Investigator, Lady Davis Institute
Professor, Departments of Medicine and Oncology, and Pharmacology and Therapeutics
Faculty of Medicine, McGill University


Dr. Alaoui-Jamali is Full Professor of Oncology and Medicine at the Faculty of Medicine, McGill University, Project Director at the Lady Davis Institute for Medical Research, and Leader of the Drug Discovery Group at the Segal Cancer Centre of the Jewish General Hospital. His research focuses on the biology of cancer progression to metastasis, anticancer drug pharmacology, and drug discovery. The accumulation of genomic and proteomic databases for the complex metastatic disease, together with advances in technology platforms, have paved the way to increased molecular understanding of cellular targets essential for the spread of cancer beyond primary sites. Dr. Alaoui-Jamali's team is exploiting newer technologies to identify, understand, and develop “smart” drugs against key invasive cancer cell targets for therapeutic intervention. This challenge is particularly demanding in the case of advanced cancer, where a large number of genetic changes affecting multiple cell regulatory pathways occur. Another interest of this team is to understand and tackle drug resistance mechanisms associated with relapses and often seen with most clinically used therapeutic agents.

Dr. Alaoui-Jamali’s research has been published in over 100 international peer-reviewed biomedical and medical oncology journals and honoured at several international conferences, including the American Association for Cancer Research, the American Society of Clinical Oncology, the Canadian Society of Otolaryngology, and the American Head and Neck Society. He serves on several national and international grant panels, the editorial boards of biomedical journals, and has edited books and book chapters related to the field of oncology science. His research has been supported by the Canadian Institutes for Health Research (CIHR), the Canadian Cancer Society (National Cancer Institute), the US Army Medical Research Initiative, the Quebec Breast Cancer and Prostate Cancer Foundations, the
Fonds de recherches en santé du Québec, and the Cancer Research Society.

Major Research Activities

Dr. Alaoui-Jamali’s research relates to biology of cancer progression, drug resistance, cancer biomarkers, and novel therapeutics with a focus on breast, prostate, head and neck, and liver carcinomas.

Cancer is a complex disease that involves multiple mechanisms and routes affected by a variety of tissue microenvironment, host, and acquired factors. In this respect, Dr. Alaoui-Jamali’s group has contributed to the understanding of molecular pathways that drive early cancer cell progression to metastasis in the complex tissue microenvironment.

Dr. Alaoui-Jamali’s laboratory exploits novel technologies including functional and structural proteomics and bioinformatics to identify key therapeutic targets and develop selective agents for therapeutic intervention f
or advanced cancer.

Recent Publications

Filamin A regulates focal adhesion disassembly and suppresses breast cancer cell migration and invasion. Xu Y, Bismar TA, Su J, Xu B, Kristiansen G, Varga Z, Teng L, Ingber DE, Mammoto A, Kumar R, Alaoui-Jamali MA. J Exp Med. 2010 Oct 25;207 (11):2421-37. [Epub ahead of print]

A novel experimental heme oxygenase-1-targeted therapy for hormone-refractory prostate cancer. Alaoui-Jamali MA, Bismar TA, Gupta A, Szarek WA, Su J, Song W, Xu Y, Xu B, Liu G, Vlahakis JZ, Roman G, Jiao J, Schipper HM. Cancer Res. 2009 Oct 15;69(20):8017-24.

Overexpression of SERTAD3, a putative oncogene located within the 19q13 amplicon, induces E2F activity and promotes tumor growth. Darwish H, Cho JM, Loignon M, Alaoui-Jamali MA. Oncogene. 2007 Jun 21;26(29):4319-28.

Snapshot

Dr. Alaoui-Jamali’s team has contributed to the characterization of molecular switches by which tyrosine kinase receptors of the ErbB family promote cancer cell migration and invasion.

His laboratory discovered and cloned a novel member of the TRIP gene family of transcription factors called RBT/SERTAD, which encodes for an oncoprotein involved in the regulation of cell cycle (NIH Gene bank accession # AF192529 and AF317202) and whose chromosomal location is amplified/overexpressed in malignancies such as ovarian carcinomas.

His laboratory is internationally known for investigating novel anticancer agents in in-vitro and in-vivo preclinical cancer models.

His current focus is to understand and target signalling pathways that drive early stage cancer cell invasion.

 
 
Important Links

Dr. Alaoui-Jamali's Profile at the McGill Center for Translational Research in Cancer

Dr. Alaoui-Jamali's Profile at the McGill Department of Oncology

Dr. Alaoui-Jamali's Profile at the McGill Department of Pharmacology and Therapeutics

 
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