Distinguished Lecture Series - Conférences de scientifiques émérites
Tuesday, November 7, 2017, 12:00 pm – 1:00 pm 
ClinicalTrials.gov: A window into the Clinical Research Enterprise
Deborah Zarin, M.D. {pdf}
Senior Scientist, NIH
Cognititive Science Branch
Deborah A. Zarin, M.D. has been the Director of ClinicalTrials.gov since 2005. Dr. Zarin has played a major role in the development and implementation of the key legal and policy mandates for clinical trial reporting. As part of that process, Dr. Zarin provided the scientific leadership for the creation of the first structured public database for the reporting of summary trial results. Dr Zarin’s recent research has been on the quality of trial reporting, as well as issues in the design and analysis of clinical trials. Dr. Zarin’s academic interests are in the area of evidence based clinical and policy decision making, as well as clinical trial conduct, analysis and reporting. She is the author of over 80 peer reviewed articles. Dr. Zarin graduated from Stanford University and received her doctorate in medicine from Harvard Medical School. She completed a clinical decision making fellowship, a pediatric internship, and is board certified in general psychiatry, as well as in child and adolescent psychiatry.
Host:Dr. Jonathan Kimmelman (514) 398-3306 / jonathan.kimmelman@mcgill.ca
3999, Chemin de la Côte-Ste-Catherine (corner of Legaré)

(Conférence en anglais seulement)
Thursday November 2, 2017 8:00 am - 5:00 pm
’The challenge of emerging and complex infectious diseases: honouring a champion'

Inaugural annual symposium in memory of Dr Mark Wainberg (1945-2017)

Dr Françoise Barré-Sinoussi, Nobel Laureate Institut Pasteur, Paris, France
« HIV translational science: from the first ARVs to the hope of a cure »
Dr Gerald Friedland, Yale University
« Confronting HIV and TB from the Bronx, NY to Tugela Ferry KwaZuluNatal, South Africa and Beyond »
Dr Myron Cohen, University of North Carolina Chapel Hill
« Treatment as prevention, lessons from HIV »
Ron Rosenes
« Mark Wainberg as a passionate HIV community advocate and ally »
Dr Marina Klein, McGill University Health Centre
« Towards Elimination of Hepatitis C Virus in HIV Infected Populations »
Dr Catherine Hankins, McGill University Health Centre
« HIV science to action: knowledge translation for lasting impact »
Dr Matthias Götte, University of Alberta
« Management of newly emerging infections- Lessons learned from HIV »
Location: Jewish General Hospital
Block B Amphitheatre
3755 Cote St Catherine

Monday, November 6, 2017, 12:00 pm – 1:00 pm 
Development and Functions of Macrophages – Consequences of Somatic Mosiacism
Frederic Geissmann, M.D., Ph.D. {pdf}
Professor of Immunology
Sloan Kettering Institute, New York, NY
Dr. Geissman is the William E. Snee Chair of Cancer Immunology at the Sloan Kettering Institute. His research is focused on cellular and molecular mechanisms that control the differentiation, maintenance, and physiological functions of macrophages and monocytes and their roles in tissue homeostasis and disease processes. Over the past ten years, he has investigated the developmental origin and homeostasis of macrophages and the related cell types monocytes and dendritic cells. These cells play a major role in diverse types of diseases including neurodegenerative diseases and in cancer where the cells can either restrain or promote cancer progression and metastasis. The Geissmann lab is now building on previous work to investigate mechanisms by which tissue macrophages may control tissue growth and metabolism and whether these same mechanisms play a role in cancer initiation and development. Dr. Geissman’s work is highly innovative and internationally recognized. His findings have been featured in leading publications including Cell, Science and Nature.
Hosted by: Dr. Stephanie Lehoux ext 25915 / stephanie.lehoux@mcgill.ca
3999, Chemin de la Côte-Ste-Catherine (corner of Legaré)

(Conférence en anglais seulement)
Tuesday, October 31, 2017, 12:00 pm – 1:00 pm
Blood-Cell Production: an Ideal Paradigm to Dissect Complex Human Phenotypes
Guillaume Lettre, Ph.D. {pdf}
Associate Professor of Medicine
Médecine, Université de Montréal
Dr. Guillaume Lettre is an Associate Professor of Medicine at the Montreal Heart Institute and the Université de Montréal since January 2009. He holds a Canada Research Chair in Complex Trait Genetics since November 2010. His laboratory is funded by grants from the Canadian Institutes of Health Research (CIHR), Genome Canada and Genome Quebec, the Doris Duke Charitable Foundation, the Natural Sciences and Engineering Research Council of Canada (NSERC), and the Montreal Heart Institute Foundation. In December 2008, he completed 3.5 years of postdoctoral training in the research group of Dr Joel N. Hirschhorn at the Broad Institute of Harvard and MIT and Children’s Hospital Boston. In Boston, his work focused on the identification of common genetic variants associated with complex traits (adult height, fetal hemoglobin levels (a strong modifier of severity in sickle cell disease) and body mass index) and common diseases (type-2 diabetes, hypertension) using genome-wide association studies. Dr. Lettre obtained his BSc in Biology from the Université de Sherbrooke, Canada, in 2000, an MSc in Biological Sciences from the Watson School of Biological Sciences at Cold Spring Harbor Laboratory, USA, in 2001, and his PhD in Developmental Genetics from the University of Zurich, Switzerland, in 2005.
Hosted by: Dr. Brent Richards, ext 24362, brent.richards@mcgill.ca
3999, Chemin de la Côte-Ste-Catherine (corner of Legaré)

(Conférence en anglais seulement)
Tuesday, October 24, 2017, 12:00 pm – 1:00 pm 
Breaking Bad: Lysine Methyl Signaling in Chromatin and Cancer Regulation
Or Gozani, MD, Ph.D. {pdf}
Professor in the Department of Biology
Stanford University
Dr. Gozani is a Professor in the Department of Biology at Stanford University. Dr. Gozani received his BA from UC Berkeley and his MD and PhD degrees from Harvard
Medical School. Research in the Gozani lab centers on understanding the molecular mechanisms by which protein lysine methylation regulates epigenetic programs and cellular signaling, and how disruption in these mechanisms contribute to cancer and other diseases. Work in the Gozani lab identified the PHD finger and the BAH domain as methyl lysine-binding “reader” domains and provided evidence that disrupting the read-out of histone modifications cause inherited human diseases. Current research efforts are aimed at discovery and characterization of new methyl-sensitive reader domains functioning in both chromatin and nonchromatin pathways. Another major focus of the lab is to uncover the catalytic and biological functions of the many protein lysine methyltransferases present in the human genome. Dr. Gozani is a recipient of a Burroughs Wellcome Career Award in Biomedical Sciences, a Kimmel Scholar Award, a Searle Scholar Award, and an Ellison Senior Scholar in Aging Award. Dr. Gozani is cofounder of two biotech companies: EpiCypher, Incand Athelas Therapeutics.
Hosted by: Dr. Stéphane Richard, ext 24470 / e-mail: stephane.richard@mcgill.ca
3999, Chemin de la Côte-Ste-Catherine (corner of Legaré)

(Conférence en anglais seulement)
Support research at the Lady Davis Institute - Jewish General Hospital