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The maintenance and replication of functional chromosome ends, or telomeres, is essential for genome integrity and cell survival. Cells have evolved mechanisms to regulate and monitor telomere length and integrity and coordinate these processes with DNA replication, damage response, repair and recombination. Using cell culture models, we study how telomere maintenance and synthesis contribute to cell immortalization and cancer, and how defects in telomere maintenance contribute to various premature aging genetic disorders such as dyskeratosis congenita.
The long-term objective of Chantal Autexier’s research program is to understand how telomere maintenance and genome stability is regulated, either by telomerase or the telomerase-independent homologous recombination-based Alternative Lengthening of Telomere (ALT) mechanism. Her research team’s short-term objectives are to identify and characterize specific and essential mechanisms regulating telomerase and telomere function in telomere maintenance, cellular immortalization and cancer that can be validated as specific and effective therapeutic targets in tumor cells and premature aging diseases of telomere maintenance.
Qin J, Garus A, Autexier C. Hum Mol Genet. 2024 Feb 1;33(4):318-332. doi: 10.1093/hmg/ddad180.
MacNeil, D.E., Lambert-Lanteigne, P., Qin, J., McManus, F., Bonneil, E., Thibault, P., and Autexier, C. 2021. Mar 24;41(4):e00464-20. doi: 10.1128/MCB.00464-20. Print 2021 Mar 24.
Shen, M., Young, A. and Autexier, C. 2021. DNA Repair, 2021 Apr;100:103055. doi: 10.1016/j.dnarep.2021.103055. Epub 2021 Feb 3.
MacNeil, D.E., Lambert-Lanteigne, P. and Autexier, C. 2019. Nucl. Acids Res. 2019 Jun 4;47(10):5368-5380.
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