The laboratory of Koren Mann was established in 2009 and is located within the Lady Davis Institute for Medical Research. The lab’s mission is to advance research in the field of metal exposure and toxicity. Our lab undertakes a multitude of in vivo and in vitro projects with a focus on heavy metals, exploring their properties, interactions, and consequences across various domains. By unraveling the mechanisms of how these metals interact with the body, we strive to enhance our understanding of their effects and contribute to the development of strategies for mitigating their potential harmful consequences.
One of the lab’s main outstanding features is its multidisciplinary approach, bringing experts together from various fields such as immunology, molecular biology, and bioinformatics. This collaborative effort allows for a comprehensive understanding of the complex nature of metals and will allow us to better understand their effects.
The lab has current and past research funding from the Canadian Institutes of Health Research, the Natural Sciences and Engineering Research Council of Canada, the Leukemia and Lymphoma Society of Canada, the Cancer Research Society, the Heart and Stroke Foundation of Canada and the US National Institutes of Health. Trainees have support from the Fonds de recherche du Québec-Santé, the Cole Foundation, the Canadian Institutes of Health Research, and McGill Internal Fellowships.
Tungsten is a heavy metal that accumulated in the bone and interferes with immature B cell development and differentiation. These tungsten-induced changes are correlated with altered DNA damage and repair mechanisms. There is very little information on tungsten toxicity; therefore, this project investigates whether tungsten immunotoxicity extends to mature B cell populations and to understand the mechanism behind tungsten toxicity. Current projects include the role of the SLC26A2as a tungsten importer and the GATOR1/KICSTOR complexes in mediating cell death.
Contemporary research has uncovered a role for environmental copper in the development and progression of neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. Previous research implicated non-ceruloplasmin bound copper in the aggravation of neurodegenerative phenotypes. Our research explores the role of copper in ALS progression through monitoring of copper biomarkers and analyses of copper metabolism gene expression.
Arsenic is an internationally recognized environmental contaminant affecting many parts of the world. A number of Canadians live in rural areas and are dependent on groundwater that contains unregulated amounts of arsenic. Arsenic exposure is linked to a myriad of adverse health effects, such as cancer and cardiovascular diseases, especially atherosclerosis. This project aims to investigate if sex and diet acts as a modulator of arsenic-induced immune cell heterogeneity within atherosclerotic plaque. We also aim to elucidate the consequences of co-exposures of other heavy metals such as cadmium and trying to determine the role of the arsenic-3-methyltransferase in arsenic metabolism and excretion.
Within the past decade, there has been a rapid rise in e-cigarette use among today’s youth. E-cigarettes contain a myriad of harmful chemicals and heavy metals. Despite their popularity, little is known about their health effects. This project aims to investigate the pathological effects of commercially available e-cigarette products, including atherosclerosis, fibrosis, and inflammatory effects.
Organophosphate esters (OPEs) are a class of toxic chemicals used as flame retardants and plasticizers in building materials and commercial goods. Some OPEs can harm the immune system; specifically, by disrupting the ability of macrophages to engulf and digest foreign particles and cells through phagocytosis. In the present study, we aim to test if a Canadian household dust based OPE mixture will decrease phagocytic uptake of apoptotic cells and bacterial pathogens.
Diffuse large B-cell lymphoma is a cancer of the lymphatic system causing patients to develop abnormal B lymphocytes. Approximately 30% to 40% of patients will succumb to relapsed/refractory disease. Our project uses mouse modelling to study this form of lymphoma. In particular, we have found that mutations in the transcription factor stat6 are enriched at disease relapse. Our current focus is to elucidate how this relapse contributes to remodeling of the tumor microenvironment.
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After graduating with a BSc in Biology from Nebraska Wesleyan University, Koren Mann obtained a PhD in Pathology/Immunology from Boston University School of Medicine. Following that, she completed a Postdoctoral Fellowship in Oncology at McGill, where she investigated the use of arsenic as a potential chemotherapy in cancer treatment. Today, she is the Chair of the Department of Pharmacology and Therapeutics, an Associate Member of the Department of Medicine, and a Senior Investigator at the Lady Davis Institute for Medical Research.
Mitra is a research associate in the Mann Lab. After finishing her BSc in Physiology at McGill, she began her career at the Lady Davis Institute for Medical Research. Her project explores the role of copper, a metal commonly found in drinking water, in the progression of amyotrophic lateral sclerosis.
Braeden is a PhD candidate in the Department of Pharmacology. He completed an Honours Bachelor of Science at Queen’s University with a specialization in Drug Development and Human Toxicology. His project focuses on elucidating the consequences of organophosphate esters exposure on macrophage function.
Nivetha is a PhD candidate in the Department of Experimental Medicine. She completed her BSc in Biochemistry at Concordia University. Her project focuses on how a co-exposure to metals, such as arsenic and cadmium, affects the progression of atherosclerosis.
Madelyn is a PhD student in the department of Experimental Medicine. She uses mouse modelling to study Diffuse Large B Cell Lymphoma. In particular, she has found that mutations in the transcription factor STAT6 are enriched at disease relapse, and I study how this contributes to remodeling of the tumour microenvironment.
Rowa is a PhD candidate in the department of Experimental Medicine. She completed her BSc in Microbiology and Immunology in Saudi Arabia, then completed two MScs in Genetics and Parasitology at McGill University. Her work investigates tungsten toxicity focusing on SLC2A2 as a transporter and the effects on mature B lymphocytes.
Vincenza is an MSc. Student in the Department of Pharmacology. She completed her BSc. in Pharmacology at McGill University. Her project aims to elucidate the role of e-cigarette use on the murine cardiopulmonary system. Specifically, she is focusing on metal deposition in the lungs, and the progression of atherosclerosis due to these exposures.
Nazli Zengin is an MSc. student in the Department of Pharmacology. She has a background in pharmacology and environment. Her work currently focuses on elucidating how sex and diet modulate arsenic toxicity and its immunological and cardiovascular consequences.
Andrew is an MSc. student in the Department of Pharmacology who graduated from the B.Sc. program in Biochemistry at McGill in 2021. He works on a proteomics project centred around Arsenic 3-Methyltransferase and the question about whether it serves an additional function.
Raymond is an MSc. Student in the Department of Pharmacology who completed his BSc. in Environmental Health Sciences from the UNC Chapel Hill as a as a Morehead-Cain Scholar. He received the McCall MacBain Scholarship in 2021. His project studies the mechanism of tungsten on mTORC1, a major regulator of cell growth and proliferation.
Nikola is an incoming MSc Student who completed his undergraduate degree in Microbiology and Immunology at McGill University. He is currently working on an NSERC summer project that assesses the functional characterization of macrophages exposed to arsenic using murine bone marrow-derived macrophages.
Roni is a second-year BSc student in Chemistry at McGill. As an undergraduate student, she works on various projects across the lab, but is currently focused elucidating the correlation between nonalcoholic fatty liver disease and vaping.
Wilson Miller, Lady Davis Institute for Medical Research, Montreal
Sonia del Rincon, Lady Davis Institute for Medical Research, Montreal
Carolyn Baglole, RI-MUHC, McGill University, Montreal
Jun Ding, RI-MUHC, McGill University, Montreal
Susan Gaskin, Department of Chemical Engineering, McGill University, Montreal
Bernard Robaire, Department of Pharmacology, McGill University, Montreal
Brandon Pearson, Columbia University, New York
John Wise, University of Louisville, Kentucky
Dr. Wilson Miller, Lady Davis Institute, Montreal
Dr. Sonia del Rincon, Lady Davis Institute, Montreal
Dr. Carolyn Baglole, RI-MUHC, McGill University, Montreal
Dr. Jun Ding, RI-MUHC, McGill University, Montreal
Dr. Susan Gaskin, Dep’t of Chemical Engineering, McGill University, Montreal
Dr. Bernard Robaire, Dep’t of Pharmacology McGill University, Montreal
Dr. Brandon Pearson, Columbia University, New York
Dr. John Wise, University of Louisville, Kentucky
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Nivetha Subramaniam:
Rowa Bakadlag:
Braeden Giles:
Andrew Little:
Nikola Kukolj:
Lorem ipsum dolor sit amet consectetur adipisicing elit. Maxime mollitia, molestiae quas vel sint commodi repudiandae consequuntur voluptatum laborum numquam blanditiis harum quisquam eius sed odit fugiat iusto fuga praesentium optio, eaque rerum! Provident similique accusantium nemo autem. Veritatis obcaecati tenetur iure eius earum ut molestias architecto voluptate aliquam nihil, eveniet aliquid culpa officia aut! Impedit sit sunt quaerat, odit, tenetur error, harum nesciunt ipsum debitis quas aliquid. Reprehenderit, quia.
Dr. Wilson Miller, Lady Davis Institute, Montreal
Dr. Sonia del Rincon, Lady Davis Institute, Montreal
Dr. Carolyn Baglole, RI-MUHC, McGill University, Montreal
Dr. Jun Ding, RI-MUHC, McGill University, Montreal
Dr. Susan Gaskin, Dep’t of Chemical Engineering, McGill University, Montreal
Dr. Bernard Robaire, Dep’t of Pharmacology McGill University, Montreal
Dr. Brandon Pearson, Columbia University, New York
Dr. John Wise, University of Louisville, Kentucky
Lorem ipsum dolor sit amet consectetur adipisicing elit. Maxime mollitia, molestiae quas vel sint commodi repudiandae consequuntur voluptatum laborum numquam blanditiis harum quisquam eius sed odit fugiat iusto fuga praesentium optio, eaque rerum! Provident similique accusantium nemo autem. Veritatis obcaecati tenetur iure eius earum ut molestias architecto voluptate aliquam nihil, eveniet aliquid culpa officia aut! Impedit sit sunt quaerat, odit, tenetur error, harum nesciunt ipsum debitis quas aliquid. Reprehenderit, quia. Quo neque error repudiandae fuga? Ipsa laudantium molestias eos sapiente officiis modi at sunt excepturi expedita sint? Sed quibusdam recusandae alias error harum maxime adipisci amet laborum. Perspiciatis minima nesciunt dolorem! Officiis iure rerum voluptates a cumque velit quibusdam sed amet tempora. Sit laborum ab, eius fugit doloribus tenetur fugiat, temporibus enim commodi iusto libero magni deleniti quod quam consequuntur!
Dr. Wilson Miller, Lady Davis Institute, Montreal
Dr. Sonia del Rincon, Lady Davis Institute, Montreal
Dr. Carolyn Baglole, RI-MUHC, McGill University, Montreal
Dr. Jun Ding, RI-MUHC, McGill University, Montreal
Dr. Susan Gaskin, Dep’t of Chemical Engineering, McGill University, Montreal
Dr. Bernard Robaire, Dep’t of Pharmacology McGill University, Montreal
Dr. Brandon Pearson, Columbia University, New York
Dr. John Wise, University of Louisville, Kentucky
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