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Important informations

Core Facilities

Cell Processing Centre

The Jewish General Hospital Cell Processing Centre

Location: F-13

The Jewish General Hospital Cell Processing Centre (JGH CPC) at the Lady Davis Institute for Medical Research (LDI) is designed as an enabling infrastructure to support the prosecution of early phase clinical trials of cell-based / derived therapies where processing of human cell and tissue is required as part of the study. The objective of this facility is to render accessible to the patient community cutting edge, experimental cellular pharmaceuticals for treatment of human catastrophic illnesses. It promotes development of technologies from institutional scientists as well as partnership development of technologies from other biomedical institutions, academic networks, biotechnology firms and pharmaceutical industry.

The facility comprises the Clean Room area (including SAS), as well as the Laboratory Annex supporting the Clean Room, and the adjacent mechanical room. The Clean Room is a clinical-grade, high sterility isolation facility certified ISO Class 7. It is operated by highly qualified personnel (Laboratory Director Nicoletta Eliopoulos, and Research Associate Bin Yu) with a track record of successful implementation and prosecution of custom cellular pharmaceuticals for Phase I clinical trials in patients with advanced disease. The current medical director of the JGH CPC is Dr. Lawrence Rosenberg.

The JGH CPC’s successful development is optimized within an environment of cooperation on a regional and national scale. The JGH CPC is part of the McGill family of enabling infrastructures, of the FRQS TheCell cell, tissue and gene therapy Network in the province of Quebec, and has established links with Quebec-based Medical Schools. It is also developed as a biotech and pharmaceutical service contract facility.

Instrumentation

The JGH CPC is located on the premises of the JGH Biomedical Complex, specifically in room F-13 of the Lady Davis Institute. It is a 1000 ft2 clinical grade, fully equipped, high sterility isolation facility. Equipment in the Clean Room of the JGH CPC include the following:

  • one Thermo Scientific Biological Safety Cabinet 1300 Series A2, 4ft.
  • one Forma Biological Safety Cabinet Class II A/B3, 4ft.
  • two Thermo Scientific™ Heracell™ VIOS 160i CO2 Incubators, 165 L.
  • one Laxco™ LMI-3000 Series Inverted Microscope with digital camera.
  • one Thermo Scientific™ Sorvall™ ST8R versatile table-top refrigerated Centrifuge with several rotor options.
  • one Corepoint Scientific™ White Diamond Series Refrigerator/Freezer Combination, and
  • various smaller equipment such as one Sartorius™ Entris™ II Essential Precision Balance, two Thermo Scientific™ Basic Vortex Mixers, Pipettors, etc.

Also, there are equipment in the Laboratory Annex of the JGH CPC to support the activities in the Clean Room, and these include one -80oC freezer, one refrigerator/freezer unit, one water bath, one microbiological incubator, etc.