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In the News

Paper of the Month

The LDI Paper of the Month is awarded by the LDI Director to highlight the great contributions from the Lady Davis Institute for Medical Research’s investigators and trainees.

Publications that can be considered for the award include all those found in a PubMed search in the relevant month for articles with a direct LDI affiliation. Publications can also be proposed to the LDI by e-mail at any time.

2024

Claudia Kleinman

November

Cancer Research

FOXR2 targets LHX6+/DLX+ neural lineages to drive CNS neuroblastoma
See the poster

Sonia Del Rincon

September

Science Advances

Blocking tumor-intrinsic MNK1 kinase restricts metabolic adaptation and diminishes liver metastasis

See the poster

Josie Ursini-Siegel

August

Cancer Research

The Neurodevelopmental Protein POGZ Suppresses Metastasis in Triple Negative Breast Cancer by Attenuating TGFβ Signaling
See the poster

François Mercier

July

Blood Advances

The E3 ubiquitin ligase Herc1 modulates the response to nucleoside analogs in acute myeloid leukemia
See the poster

Andrew Mouland

June

iScience

An HIV-1 CRISPR-Cas9 membrane trafficking screen reveals a role for PICALM intersecting endolysosomes and immunity

See the poster

Jonathan Afilalo

May

JAMA Cardiology

Osteosarcopenia and Mortality in Older Adults Undergoing Transcatheter Aortic Valve Replacement

See the poster

Laurent Azoulay

April

theBMJ

Combination treatment with glucagon-like peptide-1 receptor agonists and sodium-glucose co-transporter-2 inhibitors on the incidence of cardiovascular and serious renal events: population-based cohort study
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Kostas Pantopoulos

March

Blood

Excess of circulating apo-transferrin enhances dietary iron absorption
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Jerry Pelletier (Tribute)

February

PNAS

A second-generation eIF4A RNA helicase inhibitor exploits translational reprogramming as a vulnerability in triple-negative breast cancer
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Christel Renoux

January

Annals of Internal Medicine

Gabapentinoids and Risk for Severe Exacerbation in Chronic Obstructive Pulmonary Disease

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2023

Celia M.T. Greenwood

December

Journal of Bone and Mineral Research

Identifying Rare Genetic Determinants for Improved Polygenic Risk Prediction of Bone Mineral Density and Fracture Risk
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Ashley Wazana

November

Frontiers in child and adolescent psychiatry

The DREAM BIG project as a model for harmonizing early measures of parental care and parent-child interactions across epidemiological cohorts
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Brent Richards

October

Nature Communications

Alternative splicing in lung influences COVID-19 severity and respiratory diseases
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Gerald Batist

September

Cell Reports

A NRF2 inhibitor selectively sensitizes KEAP1 mutant tumor cells to cisplatin and gefitinib by restoring NRF2-inhibitory function of KEAP1 mutants
See the poster

Sonia Del Rincón

August

The Journal of Clinical Investigation

Peroxisome disruption alters lipid metabolism and potentiates anti-tumor response with MAPK-targeted therapy in melanoma
See the poster

Marc Fabian

August

The EMBO Journal

The EDC4-XRN1 interaction controls P-body dynamics to link mRNA decapping with decay
See the poster

Samy Suissa

May

Diabetes Care

Metformin and Cancer: Solutions to a Real-World Evidence Failure

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Kristian Filion

April

American Journal of Epidemiology

Use of a Statistical Adaptive Treatment Strategy Approach for Emulating Randomized Controlled Trials Using Observational Data: The Example of Blood Pressure Control Strategies for the Prevention of Cardiovascular Events Among Individuals with Hypertension at High Cardiovascular Risk
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William Foulkes

March

Nature Communications

Genomic characterization of DICER1-associated neoplasms uncovers molecular classes

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Vahab Soleimani

February

Nature Communications

Transcriptional reprogramming of skeletal muscle stem cells by the niche environment

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Brent Richards

January

Nature Genetics

Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases

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2022

Claudia Kleinman

December

Nature Genetics

K27M in canonical and noncanonical H3 variants occurs in distinct oligodendroglial cell lineages in brain midline gliomas

See the poster

Colin Crist

November

Cell Reports

The adhesion G-protein-coupled receptor Gpr116 is essential to maintain the skeletal muscle stem cell pool

See the poster

Laurent Azoulay

November

theBMJ

Novel antihyperglycaemic drugs and prevention of chronic obstructive pulmonary disease exacerbations among patients with type 2 diabetes: population based cohort study

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Andréa C. LeBlanc

October

Cell Death & Disease

Caspase-1 inhibition improves cognition without significantly altering amyloid and inflammation in aged Alzheimer disease mice

See the poster

Michael Witcher

September

PNAS

3D chromatin remodeling potentiates transcriptional programs driving cell invasion

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Andrew Mouland

August

Cell Reports

Scaffolding viral protein NC nucleates phase separation of the HIV-1 biomolecular condensate

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Stéphane Richard

April

Cell Reports

PRMT7 ablation stimulates anti-tumor immunity and sensitizes melanoma to immune checkpoint blockade

See the poster

Vahab Soleimani

March

eLife Sciences

Application of ATAC-Seq for genome-wide analysis of the chromatin state at single myofiber resolution

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Marc Fabian

February

The EMBO Journal

PABP prevents the untimely decay of select mRNA populations in human cells

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Brent Richards

January

Nature Genetics

Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe COVID-19

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2020

Andrea LeBlanc

December

Nature Communications

Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging

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Stephane Richard

November

Life Science Alliance

Genome-wide R-loop analysis defines unique roles for DDX5, XRN2, and PRMT5 in DNA/RNA hybrid resolution

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Phyllis Zelkowitz

October

The British Journal of Psychiatry

High- versus low-intensity interventions for perinatal depression delivered by non-specialist primary maternal care providers in Nigeria: cluster randomised controlled trial (the EXPONATE trial)

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Brett Thombs

September

JAMA

Accuracy of the PHQ-2 Alone and in Combination With the PHQ-9 for Screening to Detect Major Depression — Systematic Review and Meta-analysis

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Alexander Thiel

August

European Stroke Journal

Non-invasive brain stimulation as add-on therapy for subacute post-stroke aphasia: a randomized trial (NORTHSTAR)

See the poster

Andrew Mouland

July

Cell Reports

Pan-retroviral Nucleocapsid-Mediated Phase Separation Regulates Genomic RNA Positioning and Trafficking

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William Foulkes

June

The Journal of Clinical Investigation

DGCR8 microprocessor defect characterizes familial multinodular goiter with schwannomatosis

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Hyman Schipper

March

Movement Disorders

Salivary microR-153 and microR-223 Levels as Potential Diagnostic Biomarkers of Idiopathic Parkinson’s Disease

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Volker Blank

February

Cell Reports

NFE2L3 Controls Colon Cancer Cell Growth through Regulation of DUX4, a CDK1 Inhibitor

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Claudia Kleinman

January

Nature Genetics

Stalled developmental programs at the root of pediatric brain tumors

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2019

William Foulkes

December

New England Journal of Medicine

Mesenchymal Hamartoma of the Liver and DICER1 Syndrome

See the poster

Robert Platt

November

Circulation

Cardiovascular Disease-Related Morbidity and Mortality in Women With a History of Pregnancy Complications — Systematic Review and Meta-Analysis

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Christel Renoux

October

JAMA Psychiatry

Association of Aripiprazole With the Risk for Psychiatric Hospitalization, Self-harm, or Suicide

See the poster

Claudia Kleinman

September

Cancer Cell

Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27MGliomas

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Gerald Batist

and

Wilson Miller

August

Nature Medicine

Genomic and transcriptomic profiling expands precision cancer medicine: the WINTHER trial

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Antonios Douros

July

European Heart Journal

Control of blood pressure and risk of mortality in a cohort of older adults: the Berlin Initiative Study

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Antonis Koromilas

June

Nature Communications

An integrated stress response via PKR suppresses HER2+ cancers and improves trastuzumab therapy

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Brett Thombs

May

JAMA Internal Medicine

Evaluation of Journal Registration Policies and Prospective Registration of Randomized Clinical Trials of Nonregulated Health Care Interventions

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William Foulkes

April

Nature Communications

CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary

See the poster

Hyman Schipper

March

The Neuroscientist

Dentate Gyrus Immaturity in Schizophrenia

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Brent Richards

February

Nature Genetics

An atlas of genetic influences on osteoporosis in humans and mice

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Samy Suissa

January

The Lancet Respiratory Medicine

Comparative effectiveness of LABA-ICS versus LAMA as initial treatment in COPD targeted by blood eosinophils: a population-based cohort study

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2018

Kostas Pantopoulos

December

Blood

Hepcidin-mediated hypoferremic response to acute inflammation requires a threshold of Nmp6/Hjv/Smad signaling

See the poster

Andrea LeBlanc

November

Nature Communications

Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model

See the poster

Alexandre Orthwein

October

The EMBO Journal

SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice

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Stephane Richard

September

Developmental Cell

Loss of PRMT5 Promotes PDGFRa Degradation during Oligodendrocyte Differentiation and Myelination

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Susan Kahn

and

David Zukor

August

The New England Journal of Medicine

Aspirin or Rivaroxaban for VTE Prophylaxis after Hip or Knee Arthroplasty

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Christel Renoux

July

Journal of the American College of Cardiology

Non–Vitamin K Antagonist Oral Anticoagulants and Risk of Serious Liver Injury

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Samy Suissa

June

The New England Journal of Medicine

Making Sense of Triple Inhaled Therapy for COPD

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Andrea LeBlanc

May

Cell Death and Differentiation

Differential susceptibility of striatal, hippocampal and cortical neurons to Caspase-6

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See the profile

Wilson Miller

April

Journal of Clinical Investigation

MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma

See the poster

Prem Ponka

March

Blood

Inhibition of heme oxygenase ameliorates anemia and reduces iron overload in a b-thalassemia mouse model

See the poster
See the profile

Brent Richards

February

Nature Genetics

Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis

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Andrew Mouland

January

PLOS Neglected Tropical Diseases

Zika virus inhibits eIF2α-dependent stress granule assembly

See the poster