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Dr. Bruce Gottlieb
Project Director, Lady Davis Institute
Curator, Androgen Receptor Mutations Database
Adjunct Professor, School of Nursing and Member, Department of Human Genetics, McGill University

Dr. Gottlieb is currently a Project Director at the Lady Davis Institute, where he does research into the genetics of the androgen receptor. He is also an Adjunct Professor in the Faculty of Medicine, and member of the Human Genetics Department, of McGill University. He is the curator of the Androgen Receptor Gene Mutations database, which is a world wide genetic database available on the web. His present projects include an examination of how mutations in the androgen receptor gene (AR), might affect the occurrence and progression of prostate and breast cancer. To this end, he is currently working on research projects to investigate the nature of cancer genetics by examining genetic variations in both normal and cancer tissues, using laser capture microdissection and next generation sequencing techniques.

In addition, Dr. Gottlieb is a founding member of the Human Genome Variation Society, an elected member of its board, and serves on a number of their committees. He has also served as a member of the Mutation Database Initiative of HUGO, and has been awarded grants from a number of different funding sources, including the Canadian Institute for Health Research, the Fonds de la recherche en santé du Québec, as well as a number of private cancer research organizations, including the Weekend to End Breast Cancer.

Dr. Gottlieb is also an associate editor of the international genetics journal Human Mutation, as well as a consultant for the Genetics Home Reference Project of the National Institutes of Health. He is the author of more than 100 papers and abstracts, including over 50 peer-reviewed articles and chapters.

Major Research Activities

Dr. Gottlieb’s lab conducts cutting-edge research on the role of the androgen receptor in both breast and prostate cancer. It is also studying the genetics of abdominal aortic aneurysms and the significance of post transcriptional events in the development of disease. Dr. Gottlieb curates the androgen receptor gene mutations database and conducts research into genetic databases.


Recent Publications

Gottlieb B, Chalifour LE, Mitmaker B, Sheiner N, Obrand D, Abraham C, Meilleur M, Sugahara T, Bkaily G, Schweitzer M. BAK1 gene variation and abdominal aortic aneurysms. Hum Mutat. 2009 30:1043-7.

Gottlieb B, Chalifour LE, Schweitzer M. Response to: BAK1 gene variation and abdominal aortic aneurysms. – variants are likely due to sequencing of a processed gene in chromosome 20. Hum Mutat 2010 31:110-111.

Gottlieb B, Beitel LK, Alvarado, C, Trifiro M. Selection and mutation in the “new” genetics: an emerging hypothesis. Hum Genet. 2010 147:491-501.
 
Snapshot
Dr. Bruce Gottlieb is an internationally recognized authority on genetic databases and cancer genetics.

He was one of the first to describe intra-tissue genetic heterogeneity in cancer tumors.

His current focus is to investigate the origins and development of multifactorial diseases.

Dr. Gottlieb was also one of the first to find that gene mutations associated with abdominal aortic aneurysms are different in diseased tissues from blood.

He was one of the first to introduce next generation sequencing techniques to analyze the genetic make-up of cancer tissues
 
 
Important Links
Dr. Gottlieb's Publications Indexed on PubMed

Androgen Receptor Gene Mutations Database 
 
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