Tel.: 514-340-8222 ext. 23438 (office)
ext. 23432 (Lab)
moulay.alaoui-jamali@mcgill.ca
Dr. Moulay Alaoui-Jamali
 
Senior Investigator, Lady Davis Institute
Professor, Departments of Medicine and Oncology, and Pharmacology and Therapeutics
Faculty of Medicine, McGill University


Dr. Alaoui-Jamali is Full Professor of Oncology and Medicine at the Faculty of Medicine, McGill University, Project Director at the Lady Davis Institute for Medical Research, and Leader of the Drug Discovery Group at the Segal Cancer Centre of the Jewish General Hospital. His research focuses on the biology of cancer progression to metastasis, anticancer drug pharmacology, and drug discovery. The accumulation of genomic and proteomic databases for the complex metastatic disease, together with advances in technology platforms, have paved the way to increased molecular understanding of cellular targets essential for the spread of cancer beyond primary sites. Dr. Alaoui-Jamali's team is exploiting newer technologies to identify, understand, and develop “smart” drugs against key invasive cancer cell targets for therapeutic intervention. This challenge is particularly demanding in the case of advanced cancer, where a large number of genetic changes affecting multiple cell regulatory pathways occur. Another interest of this team is to understand and tackle drug resistance mechanisms associated with relapses and often seen with most clinically used therapeutic agents.

Dr. Alaoui-Jamali’s research has been published in over 150 international peer-reviewed biomedical and medical oncology journals and honoured at several international conferences, including the American Association for Cancer Research, the American Society of Clinical Oncology, the Canadian Society of Otolaryngology, and the American Head and Neck Society. He serves on several national and international grant panels, the editorial boards of biomedical journals, and has edited books and book chapters related to the field of oncology science. His research has been supported by the Canadian Institutes for Health Research (CIHR), the Canadian Cancer Society (National Cancer Institute), the US Army Medical Research Initiative, the Quebec Breast Cancer and Prostate Cancer Foundations, the Fonds de recherches en santé du Québec, and the Cancer Research Society.

Major Research Activities

Dr. Alaoui-Jamali’s research relates to biology of cancer progression, drug resistance, cancer biomarkers, and novel therapeutics with a focus on breast, prostate, head and neck, and liver carcinomas.

Cancer is a complex disease that involves multiple mechanisms and routes affected by a variety of tissue microenvironment, host, and acquired factors. In this respect, Dr. Alaoui-Jamali’s group has contributed to the understanding of molecular pathways that drive early cancer cell progression to metastasis in the complex tissue microenvironment.

Dr. Alaoui-Jamali’s laboratory exploits novel technologies including functional and structural proteomics and bioinformatics to identify key therapeutic targets and develop selective agents for therapeutic intervention for advanced cancer.

Recent Publications

Bijian K, Wernic D, Nivedha AK, Su J, Lim FPL, Miron CE, Amzil H, Moitessier N, Alaoui-Jamali MA. Novel Aurora A and Protein Kinase C (α, β1, β2, and θ) Multitarget Inhibitors: Impact of Selenium Atoms on the Potency and Selectivity. J Medicinal Chemistry(USA). 2022 Feb 24;65(4):3134-3150.

Chang CH et al. A novel orally available seleno-purine molecule suppresses triple-negative breast cancer cell proliferation and progression to metastasis by inducing cytostatic autophagy. Autophagy 2019 Mar 1:1-15.

Carnielli CM et al. Combining discovery and targeted proteomics reveals a prognostic signature in oral cancer. Nature Commun. 2018 Sep 5;9(1):3598.

Xu Y et al. Filamin A regulates focal adhesion disassembly and suppresses breast cancer cell migration and invasion. J Exp Med. 2010 Oct 25;207 (11):2421-37.

Alaoui-Jamali MA et al. A novel experimental heme oxygenase-1-targeted therapy for hormone-refractory prostate cancer. Cancer Res. 2009 Oct 15;69(20):8017-24.

Alaoui-Jamali MA et al. Regulation of multiple tumor microenvironment markers by overexpression of single or paired combinations of ErbB receptors. Cancer Res. 2003;63:3764-74.
Snapshot

Dr. Alaoui-Jamali’s team has contributed to the characterization of molecular switches by which tyrosine kinase receptors of the ErbB family promote cancer cell migration and invasion.

His laboratory discovered and cloned a novel member of the TRIP gene family of transcription factors called RBT/SERTAD, which encodes for an oncoprotein involved in the regulation of cell cycle (NIH Gene bank accession # AF192529 and AF317202) and whose chromosomal location is amplified/overexpressed in malignancies such as ovarian carcinomas.


His laboratory is internationally known for investigating novel anticancer agents in in-vitro and in-vivo preclinical cancer models.

His current focus is to understand and target signalling pathways that drive early stage cancer cell invasion.
 
 
Important Links

Dr. Alaoui-Jamali's Profile at the McGill Center for Translational Research in Cancer

Dr. Alaoui-Jamali's Profile at the McGill Department of Oncology

Dr. Alaoui-Jamali's Profile at the McGill Regenerative Medicine Network
 
Support research at the Lady Davis Institute - Jewish General Hospital