Recent Publications
Lambert-Lanteigne, P., Young, A. and Autexier, C. 2023. Complex interaction network revealed by mutation of human telomerase 'insertion in fingers' and essential N-terminal domains and the telomere protein TPP1. Journal of Biological Chemistry. J Biol Chem. 2023 Jan 14;299(3):102916. doi: 10.1016/j.jbc.2023.102916. Online ahead of print.

Muralidharan, A., Sotocinal, S.G., Yousefpour, N., Akkurt, N., Lima, L.V., Tansley, S., Parisien, M., Wang, C., Austin, J.S., Ham, B., Dutra, G.M., Rousseau, P., Maldonado-Bouchard, S., Clark, T., Rosen, S.F., Majeed, M.R., Silva, O., Nejade, R., Li, X., Donayre Pimentel, S., Nielsen, C.S., Neely, G.G., Autexier, C., Diatchenko, L., Ribeiro-da-Silva, A., and Mogil, J.S. 2022. Long-term male-specific chronic pain via telomere- and p53-mediated spinal cord cellular senescence. J. Clin. Invest.132: e151817.

Ghadaouia S., Olivier M.A., Martinez A., Kientega, T., Qin J., Lambert-Lanteigne, P., Cardin G.B., Autexier C., Malaquin N., Rodier F. 2021. Homologous recombination-mediated irreversible genome damage underlies telomere-induced senescence. Nucl. Acid Res., 49: 11690-11707.

Garus, A. and Autexier, C. 2021. Dyskerin, an essential pseudouridine synthase with multifaceted roles in ribosome biogenesis, splicing and telomere maintenance. RNA. 2021 Sep 23:rna.078953.121. doi: 10.1261/rna.078953.121. Online ahead of print.

Shen, M., Young, A. and Autexier, C. 2021. PCNA, a focus on replication stress and the alternative lengthening of telomeres pathway. DNA Repair, 2021 Apr;100:103055. doi: 10.1016/j.dnarep.2021.103055. Epub 2021 Feb 3.

MacNeil, D.E., Lambert-Lanteigne, P., Qin, J., McManus, F., Bonneil, E., Thibault, P., and Autexier, C. 2021. SUMOylation- and GAR1-dependent regulation of dyskerin nuclear and subnuclear localization. Mar 24;41(4):e00464-20. doi: 10.1128/MCB.00464-20. Print 2021 Mar 24.

Cepeda-Cañedo, E., Totten, S., Ahn, R., Savage, P., MacNeil, D.E., Hudson, J., Autexier, C., Deblois, G., Park, M., Witcher, M., Ursini-Siegel, J. 2021. The p66ShcA redox protein potentiates the cytotoxic response of triple negative breast cancers to PARP inhibitors. JCI Insight. 2021 Feb 22;6(4):e138382. doi: 10.1172/jci.insight.138382.

Qin, J. and Autexier, C. 2020. Regulation of human telomerase RNA biogenesis and localization. RNA Biology, RNA Biol. 2021 Mar;18(3):305-315. doi: 10.1080/15476286.2020.1809196. Epub 2020 Sep 2.

MacNeil, D.E., Lambert-Lanteigne, P. and Autexier, C. 2019. N-terminal residues of human dyskerin are required for interactions with telomerase RNA that prevent RNA degradation. Nucl. Acids Res. 2019 Jun 4;47(10):5368-5380.  
Dan, J., Rousseau, P., Hardikar, S., Veland, N., Wong, J., Autexier, C. and Chen, T. 2017. Zscan4 inhibits maintenance DNA methylation to regulate telomere elongation in mouse embryonic stem cells. Cell Reports, 20(8):1936-1949.
MacNeil, D.E., Bensoussan, H.J. and Autexier, C. 2016. Telomerase Regulation from Beginning to the End. Genes, 7,  1-33.
Rousseau, P., Khondaker, S., Zhu, S., Lauzon, C., Mai, S. and Autexier, C. 2016. An intact putative mouse telomerase essential N-terminal (TEN) domain is necessary for proper telomere maintenance. Biology of the Cell, 108, 96-112. Epub 2016 Feb 18.

Chu, T.W., MacNeil, D. and Autexier, C. 2016. Multiple mechanisms contribute to the cell growth defects imparted by human telomerase insertion in finger domain mutations associated with premature aging diseases. Journal of Biological Chemistry, 291, 8374-8386.

Mancini, J., Rousseau, P., Castor, K.J., Sleiman, H. and Autexier, C. 2015. Platinum (II) Phenanthroimidaloze G-Quadruplex Ligand Induces Selective Telomere Shortening in A549 cancer cells. Biochimie, 121,287-297. Epub 2015 Dec 25
Chu, T.W., D’Souza, Y. and Autexier, C. 2016. The insertion in fingers domain in human telomerase can mediate enzyme processivity and telomerase recruitment to telomeres in a TPP1-dependent manner. Molecular and Cellular Biology. 1, 210-222.

Spinella, J.F., Cassart, P., Garnier, N., Rousseau, P., Drullion, C., Richer, C., Ouimet, M., Vidal, R., Saillour, V., Healy, J., Autexier, C. and Daniel Sinnett. 2015. A rare somatic mutation in TPP1 induces telomere lengthening and apoptosis resistance in leukemia cells. BMC Cancer, 15:621-628.

Brault, M.E., Ohayon, S., Kwan, R., Bergman, H., Eisenberg, M.J., Boivin, J.F., Morin, J.F., Autexier, C. and Afilalo, J. 2014. Telomere Length and the Clinical Phenotype of Frailty in Older Adults Undergoing Cardiac Surgery. Journal of American Geriatrics Society, 62, 2205-7.

Zhu, S., Rousseau, P., Lauzon, C. Gandin, V., Topisirovic, I. and Autexier, C. 2014. Inactive C-terminal Telomerase Reverse Transcriptase Insertion Splicing Variants are Dominant-Negative Inhibitors of Telomerase. Biochimie, Jun;101:93-103. doi: 10.1016/j.biochi.2013.12.023. Epub 2014 Jan 9.

D’Souza, Y., Lauzon, C., Chu, T.W., and Autexier, C. 2013. Regulation of human telomere length and homeostasis by telomerase enzyme processivity. J. Cell Science. 126, 676-87.

D’Souza, Y., Chu, T.W., Autexier, C. 2013. A translocation-defective telomerase with low levels of activity and processivity stabilizes short telomeres and confers immortalization. Mol. Biol. Cell. 24, 1469-79. Epub 2013 Feb 27.

Brault, M.E., Lauzon, C. and Autexier, C. 2013. Dyskeratosis congenita mutations in dyskerin SUMOylation consensus sites lead to impaired telomerase RNA accumulation and telomere defects. Hum. Mol. Genet. 22, 3498-507.

Shawi, M., Chu, T.W., Martinez-Marignac, V., Yu, Y., Gryaznov, S., Johnson, J.B. , Lees-Miller, S.P. Assouline, S.E., Autexier, C. and Aloyz, R. 2013. Telomerase contributes to fludarabine resistance in quiescent human primary leukemic lymphocytes.
Support research at the Lady Davis Institute - Jewish General Hospital