Donna Senger, PhD

 Donna Senger’s specific research interests include:

• Pediatric and adult central nervous system tumours including defining the molecular characteristics with a specific interest in investigating the brain microenvironment and how it impacts the growth and progression of brain tumours. Pr. Senger has established a track record of taking some of the discoveries from the bench to the clinic.
• Identification and implementation of therapeutics for the development of organ specific cancer metastasis with a particular emphasis in the areas of melanoma and osteosarcoma and the role inflammatory pathways play in these processes. Specifically, Pr. Senger is interested in identifying adhesion molecules expressed on specific organ endothelium.
• Establishment of a preclinical in vivo drug-screening core and a “live” pediatric tumour bank that focuses on the establishment of pediatric-patient-derived-xenografts from rare cancers with a specific focus in the area of brain tumours, sarcomas and neuroblastoma. These activities support the Terry Fox PROFYLE (Precision Oncology for Young People) Model Systems Node.