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Koren Mann’s laboratory investigates the mechanisms by which arsenic acts as a pro-atherogen and enhances the formation of atherosclerotic lesions. Using a combination of mouse models and in vitro cell cultures, she has shown that arsenic causes macrophages to accumulate fat by inhibiting the molecular cues of lipid efflux. Currently, she is focusing on the role of arsenic methylation in the pro-atherosclerotic effects of arsenic and using single cell technologies to interrogate the cellular heterogeneity and cell-cell communication within the plaque.
Koren Mann’s laboratory is also studying the potential toxicities associated with tungsten exposure including effects of developing B lymphocytes, bone, and breast cancer metastases. Exposure to tungsten has been proposed as a possible cause for several leukemia clusters.
As part of the Lymphoma Translational Research Group, Pr. Mann participates in correlative studies in diffuse large B cell lymphoma clinical trials. She has an interest in the molecular changes in tumors from patients that relapse or are refractory to standard chemotherapy.
Koren Mann’s research focuses on metal toxicology.
The specific research areas in the laboratory include:
Makhani K, Chiavatti C, Negro Silva LF, Lemaire M, Bolt AM, De Jay N, Giles B, Zengin AN, Kleinman CL, Mann KK. Toxicol Sci. 2023 Mar 20;192(1):83-96. doi: 10.1093/toxsci/kfad001. PMID: 36617169
Negro Silva LF, Makhani K, Lemaire M, Lemarié CA, Plourde D, Bolt AM, Chiavatti C, Bohle DS, Lehoux S, Goldberg MS, Mann KK. Environ Health Perspect. 2021 May;129(5):57008. doi: 10.1289/EHP8171. Epub 2021 May 17.PMID: 34014776
Chou H, Grant MP, Bolt AM, Guilbert C, Plourde D, Mwale F, Mann KK. Toxicol Sci. 2021 Jan 6;179(1):135-146. doi:10.1093/toxsci/kfaa165. PMID: 33146397
Assouline SE, Nielsen TH, Yu S, Alcaide M, Chong L, MacDonald D, Tosikyan A, Kukreti V, Kezouh A, Petrogiannis-Haliotis T, Albuquerque M, Fornika D, Alamouti S, Froment R, Greenwood CM, Oros KK, Camglioglu E, Sharma A, Christodoulopoulos R, Rousseau C, Johnson N, Crump M, Morin RD, Mann KK. Blood. 2016 Jul 14;128(2):185-94. doi: 10.1182/blood-2016-02-699520. Epub 2016 May 10. PMID: 27166360
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