Aucun résultat
Rongtuan Lin’s laboratory has a long-standing interest in investigating the virus-host interaction and understanding the impact of viral infection on host transcription control and viral pathogenesis. Their current interests include the use of small molecules that mimic viral RNA to inhibit pathogenic virus infection.
Their group has characterized the kinases (IKKi and TBK1) and the transcription factors (IRF-3 and 7) as essential cellular factors to trigger antiviral immune response; and demonstrated the capacity of small molecules agonist of RIG-I to stimulate a strong antiviral immune response and to inhibit influenza, Dengue, and other pathogenic human viruses.
Rongtuan Lin’s research program is to characterize the positive and negative regulation of antiviral innate immune response, determine the impact of virus-host cell interactions on the initiation and regulation of innate immune signaling, and develop novel strategies to control and prevent virus infection.
The specific research areas in the laboratory include:
Zhang X, Choi JH, Dai DL, Luo J, Ladak RJ, Li Q, Wang Y, Zhang C, Wiebe S, Liu ACH, Ran X, Yang J, Naeli P, Garzia A, Zhou L, Mahmood N, Deng Q, Elaish M, Lin R, Mahal LK, Hobman TC, Pelletier J, Alain T, Vidal SM, Duchaine T, Mazhab-Jafari MT, Mao X, Jafarnejad SM, Sonenberg N. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2204539119. doi: 10.1073/pnas.2204539119. Epub 2022 Jul 25. PMID: 35878012
Zhao J, Zhang G, Zhang Y, Yi D, Li Q, Ma L, Guo S, Li X, Guo F, Lin R, Luu G, Liu Z, Wang Y, Cen S. Antiviral Res. 2021 Dec;196:105209. doi: 10.1016/j.antiviral.2021.105209. Epub 2021 Nov 18. PMID: 34801588
Zhang X, Chapat C, Wang P, Choi JH, Li Q, Luo J, Wiebe S, Kim SH, Robichaud N, Karam IF, Dai D, Hackett AP, Lin R, Alain T, Yang L, Jafarnejad SM, Sonenberg N. Mol Cell. 2021 Mar 18;81(6):1187-1199.e5. doi: 10.1016/j.molcel.2021.01.030. Epub 2021 Feb 12. PMID: 33581076.
Cao L, Liu S, Li Y, Yang G, Luo Y, Li S, Du H, Zhao Y, Wang D, Chen J, Zhang Z, Li M, Ouyang S, Gao X, Sun Y, Wang Z, Yang L, Lin R, Wang P, You F. Cell Host Microbe. 2019 Sep 11;26(3):369-384. doi:10.1016/j.chom. 2019.08.010. PMID:31513772
You have the power to make a difference! Your gift will support vital research at the Lady Davis Institute for Medical Research (LDI) that will translate into disease prevention, improved diagnoses, earlier detection, new and enhanced therapies, a better quality of life, wellness and hope for all of us.
Faire la différence, vous avez ce don! Votre contribution soutiendra la recherche essentielle menée à l’Institut Lady Davis qui permettra la prévention des maladies, des diagnostics plus précis, des dépistages plus rapides, des traitements innovants et plus performants, une meilleure qualité de vie, le bien-être et l’espoir pour nous tous.
Copyright © 2024 | Lady Davis Institute for Medical Research/Jewish General Hospital
Conception et développement : Yankee Media