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Cardiovascular diseases, the most prevalent cause of death in Canada, usually result from atherosclerosis. During atherogenesis, elevated plasma lipids and inflammation lead to the accumulation of monocytes/macrophages, other leukocytes, and smooth muscle cell in the arterial wall, which in turn contribute to plaque growth and encroachment in the vascular lumen. Clinical events arise when the atherosclerotic plaque impedes blood low, either through gradual lesion growth of because of sudden rupture or erosion of the plaque. Over the years, we have established a diverse research program spanning biomechanical factors to molecular biology to immunology, as we strive to understand why plaques form and how lesion formation can be reduced or reversed.
Cardiovascular diseases, the most prevalent cause of death in Canada, usually result from atherosclerosis. During atherogenesis, elevated plasma lipids and inflammation lead to the accumulation of monocytes/macrophages, other leukocytes, and smooth muscle cell in the arterial wall, which in turn contribute to plaque growth and encroachment in the vascular lumen. Clinical events arise when the atherosclerotic plaque impedes blood low, either through gradual lesion growth of because of sudden rupture or erosion of the plaque.
Over the years, we have established a diverse research program spanning biomechanical factors to molecular biology to immunology, as we strive to understand why plaques form and how lesion formation can be reduced or reversed. Our projects include:
Ebrahimian T, Dierick F, Ta V, Kotsiopriftis M, O’Connor Miranda J, Mann KK, Orthwein A, Lehoux S. Sci Rep. 2023;13(1):8723
DiStasio N, Dierick F, Ebrahimian T, Tabrizian M*, Lehoux, S*. Acta Biomaterialia. 2022; 15;143:356-371.
Ebrahimian T, Dierick F, Simon D, Heidari M, Orthwein A, Mann KK, Lehoux S. Immunohorizons. 2020;4(5):259-273.
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