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Stephen Robbins’ laboratory has had a long-standing interest in how extracellular signals are communicated to the cell to control such essential biological processes as the growth and differentiation of mammalian cells. They have been particularly interested in how this complex biochemical circuitry can go awry in the setting of cancer and how it can be targeted for therapeutic intervention.
With a greater understanding of the molecular drivers of tumor progression the Robbins laboratory are translating their findings using a wide range of pre-clinical models with the ultimate goal of testing them in the clinic to improve patient outcomes. Their specific focus is in the area of hard-to-treat cancers including
Their studies have moved beyond the cancer cell per se and now include strategies to investigate how the tumor microenvironment fuels cancer cell proliferation and imparts therapeutic resistance to our current therapies.
Our research program aims to understand the role of the innate immune system in tumorigenesis, metastasis and therapeutic resistance. We also have specific interest in how leukocytes are recruited to specific organs during an inflammatory response on how dampening inflammation can be applied clinically.
The specific research areas in the laboratory include:
De Boeck A, Ahn BY, D’Mello C, Lun X, Menon SV, Alshehri MM, Szulzewsky F, Shen Y, Khan L, Dang NH, Reichardt E, Goring KA, King J, Grisdale CJ, Grinshtein N, Hambardzumyan D, Reilly KM, Blough MD, Cairncross JG, Yong VW, Marra MA, Jones SJM, Kaplan DR, McCoy KD, Holland EC, Bose P, Chan JA, Robbins SM, Senger DL. Nat Commun. 2020 Oct 5;11(1):4997. doi: 10.1038/s41467-020-18569-4. PMID: 33020472.
Rahn JJ, Lun X, Jorch SK, Hao X, Venugopal C, Vora P, Ahn BY, Babes L, Alshehri MM, Cairncross JG, Singh SK, Kubes P, Senger DL, Robbins SM. Biomaterials. 2020 Sep;252:120105. doi: 10.1016/j.biomaterials.2020.120105. Epub 2020 May 7. PMID: 32417652.
Choudhury SR, Babes L, Rahn JJ, Ahn BY, Goring KR, King JC, Lau A, Petri B, Hao X, Chojnacki AK, Thanabalasuriar A, McAvoy EF, Tabariès S, Schraeder C, Patel KD, Siegel PM, Kopciuk KA, Schriemer DC, Muruve DA, Kelly MM, Yipp BG, Kubes P, Robbins SM, Senger DL. Cell. 2019 Aug 22;178(5):1205-1221.e17. doi: 10.1016/j.cell.2019.07.017. PMID: 31442408.
Lun X, Wells JC, Grinshtein N, King JC, Hao X, Dang NH, Wang X, Aman A, Uehling D, Datti A, Wrana JL, Easaw JC, Luchman A, Weiss S, Cairncross JG, Kaplan DR, Robbins SM, Senger DL. Clin Cancer Res. 2016 Aug 1;22(15):3860-75. doi: 10.1158/1078-0432.CCR-15-1798. Epub 2016 Mar 22. PMID: 27006494 .
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