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Koren Mann

Koren Mann, PhD

Molecular & Regenerative Medicine

Arsenic, Atherosclerosis, Diffuse large B cell lymphoma, Immune toxicity, Metal toxicity, Tungsten
  • Senior Investigator, Lady Davis Institute for Medical Research
  • Professor and Chair, Department of Pharmacology and Therapeutics, McGill University

Contact details

(514) 340-8222 ext. 22760
koren.mann@mcgill.ca
@KorenMann

Assistant contact details

  • Cynthia Guilbert,
    Laboratory Manager
    (514) 340-8222 ext. 24257
    cynthia.guilbert@ladydavis.ca

Snapshot

Koren Mann’s laboratory investigates the mechanisms by which arsenic acts as a pro-atherogen and enhances the formation of atherosclerotic lesions. Using a combination of mouse models and in vitro cell cultures, she has shown that arsenic causes macrophages to accumulate fat by inhibiting the molecular cues of lipid efflux. Currently, she is focusing on the role of arsenic methylation in the pro-atherosclerotic effects of arsenic and using single cell technologies to interrogate the cellular heterogeneity and cell-cell communication within the plaque.

Koren Mann’s laboratory is also studying the potential toxicities associated with tungsten exposure including effects of developing B lymphocytes, bone, and breast cancer metastases. Exposure to tungsten has been proposed as a possible cause for several leukemia clusters.

As part of the Lymphoma Translational Research Group, Pr. Mann participates in correlative studies in diffuse large B cell lymphoma clinical trials. She has an interest in the molecular changes in tumors from patients that relapse or are refractory to standard chemotherapy.

Read more

Important Links :

See Koren Mann's publications on PubMed

Major Research Activities

Koren Mann’s research focuses on metal toxicology.

 

The specific research areas in the laboratory include:

  • Immunotoxicology
  • Atherosclerosis
  • Carcinogenesis
  • Leukemia and lymphoma
  • e-cigarettes and vaping

Recent Publications and References