Aucun résultat
Epigenetic processes play a central role in controlling cell survival, proliferation, migration and differentiation. We aim to understand how deregulation of epigenetic processes influence tumor growth and metastasis in breast and ovarian cancers. We employ genomic approaches to map epigenetic factors across cancer genomes. By doing so, deregulation of key oncogenic networks are often revealed. Using this information, we strive to rationally predict new therapeutic interventions that will restore the epigenome to normalcy, thereby reversing the potential of cancer cells to grow or metastasize.
Epigenetic processes play a central role in controlling cell survival and differentiation. Our lab is focused on understanding how deregulation of epigenetic processes in breast and ovarian cancers lead to tumor growth and metastasis. By understanding these mechanisms, we aim to uncover new therapeutic avenues to treat poor prognosis breast and ovarian cancers.
Lebeau B, Jangal M, Zhao T, Wong CK, Wong N, Cañedo EC, Hébert S, Aguilar-Mahecha A, Chabot C, Buchanan M, Catterall R, McCaffrey L, Deblois G, Kleinman C, Park M, Basik M, Witcher M. Proc Natl Acad Sci U S A. 2022 Sep 6;119(36):e2203452119. doi: 10.1073/pnas.2203452119.
Lebeau B, Zhao K, Jangal M, Zhao T, Guerra M, Greenwood CMT, Witcher M. Nucleic Acids Res. 2022 Aug 26;50(15):8441-8458. doi: 10.1093/nar/gkac658.
Cañedo EC, Totten S, Ahn R, Savage P, MacNeil D, Hudson J, Autexier C, Deblois G, Park M, Witcher M, Ursini-Siegel J. JCI Insight. 2021 Feb 22;6(4):e138382. doi: 10.1172/jci.insight.138382.
Shorstova T, Marques M, Su J, Johnston J, Kleinman CL, Hamel N, Huang S, Alaoui-Jamali MA, Foulkes WD, Witcher M. Cancer Res. 2019 May 15;79(10):2761-2774. doi: 10.1158/0008-5472.CAN-18-1545.
You have the power to make a difference! Your gift will support vital research at the Lady Davis Institute for Medical Research (LDI) that will translate into disease prevention, improved diagnoses, earlier detection, new and enhanced therapies, a better quality of life, wellness and hope for all of us.
Faire la différence, vous avez ce don! Votre contribution soutiendra la recherche essentielle menée à l’Institut Lady Davis qui permettra la prévention des maladies, des diagnostics plus précis, des dépistages plus rapides, des traitements innovants et plus performants, une meilleure qualité de vie, le bien-être et l’espoir pour nous tous.
Copyright © 2024 | Lady Davis Institute for Medical Research/Jewish General Hospital
Conception et développement : Yankee Media
