Senior Investigator, Lady Davis Institute
Assistant Professor, Departments of Surgery and Oncology, McGill University
Dr. Basik is a surgical oncologist, and member of the Departments of Oncology and Surgery at McGill University. His laboratory’s areas of investigation are gene expression and DNA changes in breast and colon cancers. It is part of the Montreal Centre for Experimental Therapeutics in Cancer, located at the Lady Davis Institute for Medical Research.
Major Research Activities
Using modern microarray technology, Dr. Basik's laboratory is investigating the relationship between DNA copy number changes and gene expression across the genome in both cell lines and primary tumors. One goal is to find genes that are overexpressed, as well as amplified, in cancers. These genes will then be candidate targets for novel anti-cancer therapies. They will be functionally validated using small interfering RNA approaches, and clinically validated using tissue microarrays constructed at the laboratory. Another goal is to discover novel tumor suppressor genes using a combination of microarray technologies and manipulations of the nonsense-mediated RNA decay system. Both novel tumor suppressor genes and amplified genes will also be studied as potential new diagnostic markers in breast and colon cancer. The lab has a special focus on markers of breast cancer metastasis, specifically chemokines and their receptors (CXCR4). We are also investigating mechanisms of resistance to novel biologics such as herceptin. Finally, we are part of the FRSQ Reseau de Cancer axe cancer du sein/ovaire, and, as such, are actively participating in a province-wide breast tumor banking, as well as placing primary breast tumors into primary culture. A particular interest is stromal-epithelial interactions active in breast tumor biology.