Recent Publications
Dan, J., Rousseau, P., Hardikar, S., Veland, N., Wong, J., Autexier, C. and Chen, T. 2017. Zscan4 inhibits maintenance DNA methylation to regulate telomere elongation in mouse embryonic stem cells. Cell Reports, 20(8):1936-1949.
MacNeil, D.E., Bensoussan, H.J. and Autexier, C. 2016. Telomerase Regulation from Beginning to the End. Genes, 7, 1-33.
Rousseau, P., Khondaker, S., Zhu, S., Lauzon, C., Mai, S. and Autexier, C. 2016. An intact putative mouse telomerase essential N-terminal (TEN) domain is necessary for proper telomere maintenance. Biology of the Cell, 108, 96-112. Epub 2016 Feb 18.

Chu, T.W., MacNeil, D. and Autexier, C. 2016. Multiple mechanisms contribute to the cell growth defects imparted by human telomerase insertion in finger domain mutations associated with premature aging diseases. Journal of Biological Chemistry, 291, 8374-8386.

Mancini, J., Rousseau, P., Castor, K.J., Sleiman, H. and Autexier, C. 2015. Platinum (II) Phenanthroimidaloze G-Quadruplex Ligand Induces Selective Telomere Shortening in A549 cancer cells. Biochimie, 121,287-297. Epub 2015 Dec 25
Chu, T.W., D’Souza, Y. and Autexier, C. 2016. The insertion in fingers domain in human telomerase can mediate enzyme processivity and telomerase recruitment to telomeres in a TPP1-dependent manner. Molecular and Cellular Biology. 1, 210-222.

Spinella, J.F., Cassart, P., Garnier, N., Rousseau, P., Drullion, C., Richer, C., Ouimet, M., Vidal, R., Saillour, V., Healy, J., Autexier, C. and Daniel Sinnett. 2015. A rare somatic mutation in TPP1 induces telomere lengthening and apoptosis resistance in leukemia cells. BMC Cancer, 15:621-628.

Brault, M.E., Ohayon, S., Kwan, R., Bergman, H., Eisenberg, M.J., Boivin, J.F., Morin, J.F., Autexier, C. and Afilalo, J. 2014. Telomere Length and the Clinical Phenotype of Frailty in Older Adults Undergoing Cardiac Surgery. Journal of American Geriatrics Society, 62, 2205-7.

Zhu, S., Rousseau, P., Lauzon, C. Gandin, V., Topisirovic, I. and Autexier, C. 2014. Inactive C-terminal Telomerase Reverse Transcriptase Insertion Splicing Variants are Dominant-Negative Inhibitors of Telomerase. Biochimie, Jun;101:93-103. doi: 10.1016/j.biochi.2013.12.023. Epub 2014 Jan 9.

D’Souza, Y., Lauzon, C., Chu, T.W., and Autexier, C. 2013. Regulation of human telomere length and homeostasis by telomerase enzyme processivity. J. Cell Science. 126, 676-87.

D’Souza, Y., Chu, T.W., Autexier, C. 2013. A translocation-defective telomerase with low levels of activity and processivity stabilizes short telomeres and confers immortalization. Mol. Biol. Cell. 24, 1469-79. Epub 2013 Feb 27.

Brault, M.E., Lauzon, C. and Autexier, C. 2013. Dyskeratosis congenita mutations in dyskerin SUMOylation consensus sites lead to impaired telomerase RNA accumulation and telomere defects. Hum. Mol. Genet. 22, 3498-507.

Shawi, M., Chu, T.W., Martinez-Marignac, V., Yu, Y., Gryaznov, S., Johnson, J.B. , Lees-Miller, S.P. Assouline, S.E., Autexier, C. and Aloyz, R. 2013. Telomerase contributes to fludarabine resistance in quiescent human primary leukemic lymphocytes.
PLoS One, Jul 29;8(7):e70428.

Fragnet, L., Marie-Egyptienne, D.T., Fakhoury, J., Rasschaert, D. and Autexier, C. 2012. The human telomerase catalytic subunit and viral telomerase RNA reconstitute a functional telomerase complex in a cell free system but not in human cells.
Cellular and Molecular Biology Letters, 17, 598-615.

Mancini, J. and Autexier, C. 2012. The telomerase complex: An overview. In: Telomerases: Chemistry, Biology and Clinical Applications. Chantal Autexier and Neal Lue, eds. John Wiley & Sons, Inc. Publishers, NJ.

Castor, K., Mancini, J., Fakhoury, J., Weill, N., Kieltyka, R., Englebienne, P., Avakyan, N., Langille,A., Mittermaier, A., Autexier, C., Moitessier, N., Sleiman, H.F. 2012. Platinum(II) phenanthroimidazoles for targeting telomeric G-quadruplexes. ChemMedChem, 7, 85-94. Epub 2011 Nov 3.

Brault, M.E. and Autexier, C. 2011. Telomeric recombination is induced by dysfunctional telomeres. Mol. Biol. Cell. 22, 179-188. Epub 2010 Nov 30.

Brault, M.E. and Autexier, C. 2011. ALTered telomeres in response to telomere dysfunction. Cell Cycle, 10, 3807-9. Epub 2011 Nov 15.

Fakhoury, J., Marie-Egyptienne, D.T., Londoño-Vallejo J.A. and Autexier, C. 2010. Telomeric function of mammalian telomerases at short telomeres. J. Cell Science. 123, 1693-704.

Marie-Egyptienne, D.T., Brault, M.E., Nimmo, G.A.M., Londoño-Vallejo J.A.and Autexier, C. 2009. Growth defects in mouse cells expressing mutant-template mouse telomerase RNA. Cancer Lett. 275, 266-276.

Kieltyka, R., Englebienne, P., Fakhoury, J., Autexier, C., Moitessier, N., and Sleiman, H. 2008. A platinum supramolecular square as an effective G-Quadruplex binder and telomerase inhibitor. J. Am. Chem. Soc. 130, 10040-10041.

Marie-Egyptienne, D.T., Brault, M.E., Zhu, S. and Autexier, C. 2008. Telomerase inhibition in a mouse cell line with long telomeres leads to rapid telomerase reactivation. Exp. Cell Res. 314, 668-675.

Autexier, C. 2008. POT of gold: modeling dyskeratosis congenita in the mouse. Genes & Development, 22, 1731-1736.

Shawi, M. and Autexier, C. 2008. Telomerase, senescence and aging. Mechanisms of Ageing and Development, 129, 3-10.

Fakhoury, J., Nimmo, G.A.M. and Autexier, C. 2007. Harnessing telomerase in cancer therapeutics. Anti-Cancer Agents in Medicinal Chemistry 7, 475-483.

Brault, M.E., D’Souza, Y. and Autexier, C. 2007. Telomerase structure, function and evolution. In: Origin and Evolution of Telomeres. Lubo Tomaska and Jozef Nosek, eds. and Kluwer Academic/Plenum Publishers, New York, NY.

Jain, P., Cerone, M.A, LeBlanc, A.C. and Autexier, C. 2007. Telomerase and neuronal marker status of differentiated NT2 and SK-N-SH human neuronal cells and primary human neurons. Journal of Neuroscience Research, 85, 83-89.
Support research at the Lady Davis Institute - Jewish General Hospital